Vonoprazan is a potassium-competitive acid blocker used in the treatment of erosive diseases of the digestive tract, including reflux esophagitis and duodenal ulcers.

Indications

Vono-Q (Vonoprazan) is indicated for:

• Gastric ulcer,
• duodenal ulcer
• reflux esophagitis
• prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration
• prevention of recurrence of gastric or duodenal ulcer during non-steroidal anti-inflammatory drug (NSAID) administration.

Adjunct to helicobacter pylori eradication in the following settings:

• Gastric ulcer,
• duodenal ulcer
• gastric mucosa-associated lymphatic tissue (MALT) lymphoma
• idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer or helicobacter pylori gastritis.

Dose

Gastric ulcer and duodenal ulcer

The usual adult dosage for oral use is 20mg of vono-Q (Vonoprazan) administered orally once daily an 8-week treatment for gastric ulcer and a 6-week treatment for duodenal ulcer.

Reflux esophagitis

The usual adult dose for oral use is 20mg of vono-Q(Vonoprazan) administered once daily for a total of 4 weeks of treatment. If that dosing proves insufficient, the administration should be extended, but for no longer than 8 weeks of treatment.

For the maintenance therapy of reflux esophagitis showing recurrence and recrudescence, the dose for oral use is 10mg of vono-Q (vonoprazan) once daily. However, when the efficacy is inadequate, the dosage may be increase up to 20mg of vono-Q (vonoprazan) once daily

Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration

The usual adult dosage is one tablet of 10mg of vono-Q (vonoprazan) administered orally once daily.

Prevention of recurrence of gastric or duodenal ulcer during non-steroidal anti-inflammatory drug (NSAID) administration

The usual adult dosage is one tablet of 10mg of vono-Q (Vonoprazan) administered orally once daily

Adjunct to Helicobacter pylori eradication

For adults, the following three-drug regimen should be administered orally at the same time twice daily for seven days: 20mg of vono-Q (Vonoprazan),750mg of amoxicillin hydrate and 200mg of clarithromycin.

The dosage of clarithromycin may be increased as clinically warranted. However, dosage should not exceed 400mg twice daily.

If Helicobacter pylori eradication with a three-drug regimen comprising a proton pump inhibitor, amoxicillin hydrate and clarithromycin has been unsuccessful as an alternative treatment, adults should be administered the following three drugs orally twice daily for seven days: 20mg of vono-Q (Vonoprazan),750mg of amoxicillin hydrate and 250mg of metronidazole.